國家衛生研究院 NHRI:Item 3990099045/10729
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    题名: Different axonal dysfunction pattern in seropositive and seronegative sjogren's syndrome
    作者: Tani, J;Liao, HT;Hsu, HC;Chen, LF;Lin, CSY;Chang, TS;Sung, JY
    贡献者: NHRI Graduate Student Program
    摘要: Sjögren’s syndrome (SS) is an autoimmune disease that affects both East and West. Nevertheless, we still have limited knowledge of how autoantibodies in SS affects the peripheral nervous system. In this study, we investigated the peripheral neuropathy in SS and sicca complex using the nerve excitability test, to elucidate how peripheral nerves are affected. We have enrolled a total of 22 patients with SS or sicca complex. Of these, two patients were excluded due to co-morbid carpal tunnel syndrome. Each patient received clinical evaluation, examination for SSA/SSB antibodies titer, the nerve excitability test, conventional thermal quantitative sensory test ,and conventional nerve conduction study. Compared to 33 normal control subjects, motor nerve excitability test of SS patients with positive SSA or SSB antibodies (n = 14) were found to have increased rheobase (P < 0.05), increased relative refractory period(RRP)(P < 0.01),increased refractoriness at 2.5 ms (P < 0.01), increased accommodation toward depolarizing current in threshold electrotonus (TE) (P < 0.05), and decreased super excitability (P < 0.05). The sensory axonal study in seropositive SS also revealed increased RRP (P < 0.01), increased refractoriness at 2.5 ms (P < 0.01), and increased accommodation toward hyperpolarizing current in threshold electrotonus (TE) (P < 0.05). Meanwhile, in seronegative SS and sicca complex (n = 6), we found no significant axonal properties changes. The present study revealed that peripheral nerves are affected differently in seropositive SS and in seronegative SS/sicca complex. In seropositive SS, motor axons tended to be depolarized, and both sensory and motor axons have increased refractoriness. The findings suggested that SSA and SSB antibodies might play a role in the inactivation of transient sodium channels. The effects of the antibodies on transient sodium channels might be the basis of peripheral neuropathies and even cardiac arrhythmias and heart block in SS.
    日期: 2017-09
    關聯: Journal of the Peripheral Nervous System. 2017 Sep;22(3):393.
    Link to: http://dx.doi.org/10.1111/jns.12225
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1085-9489&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000409243500418
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