國家衛生研究院 NHRI:Item 3990099045/10758
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    題名: Statin use is associated with decreased asthma-related emergency department visits and hospital admissions
    作者: Tsai, H;Wang, J;Yao, T;Tsai, Y;Wu, A
    貢獻者: Institute of Population Health Sciences
    摘要: Introduction: Statins have pleiotropic anti-inflammatory and immunomodulatory effects, but the effect of statin use on asthmarelated emergency department (ED) visits and hospital admissions has remained unclear, especially in Asian populations. Objectives: The aim of our study was to examine the effect of statin therapy on asthma-related ED visits and hospital admissions using a large nationwide population-based cohort. Results: There were 1946 asthma-related ED visits and hospital admissions in this study. The incidence rate of asthma-related ED visits and hospital admissions among statin users was 10.8 per 1000 person-years (95% confidence interval (CI): 11.4-11.3). Statin users were associated with a reduced risk of asthma-related ED visits or hospital admissions (adjusted hazard ratio [aHR]: 0.71; 95%CI: 0.620.92) compared to non-statin users. In addition, the risk of asthmarelated ED visits and hospital admissions was decreased among those with a higher cumulative defined daily dose (DDD), greater average DDD and longer cumulative-day users than the counterparts. Conclusions: Statin use is associated with decreased risk of asthma-related ED visits and/or hospital admissions in individuals with asthma. Further investigations on underlying regulatory mechanisms will be merited.
    日期: 2017-08
    關聯: Allergy. 2017 Aug;72(Suppl. 103, SI):414.
    Link to: http://dx.doi.org/10.1111/all.13252
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000408773103061
    顯示於類別:[蔡慧如] 會議論文/會議摘要

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