國家衛生研究院 NHRI:Item 3990099045/10773
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10773


    Title: Magnesium oxide use and reduced risk of dementia: A retrospective, nationwide cohort study in Taiwan
    Authors: Tzeng, NS;Chung, CH;Lin, FH;Huang, CF;Yeh, CB;Huang, SY;Lu, RB;Chang, HA;Kao, YC;Yeh, HW;Chiang, WS;Chou, YC;Tsao, CH;Wu, YF;Chien, WC
    Contributors: Center for Neuropsychiatric Research
    Abstract: OBJECTIVE: Dietary magnesium may be associated with a lower risk of dementia, however, the impact of magnesium oxide (MgO), a common laxative, on dementia has yet to be elucidated. This study aimed to investigate the association between the usage of MgO and the risk of developing dementia. METHODS: We used a dataset from the National Health Research Institute Database (NHRID) of Taiwan containing one million randomly sampled subjects to identify patients aged >/= 50 years with no history of MgO usage. A total of 1,547 patients who had used MgO were enrolled, along with 4,641 controls who had not used the MgO propensity score-matched by age, gender, and comorbidity, at a ratio of 1:3. After adjusting for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing dementia during a 10-year follow-up period. RESULTS: Of the enrolled patients, 44 (2.84%) developed dementia, when compared to 199 (4.28%) in the control group. The Cox proportional hazards regression analysis revealed that the patients who had used MgO were less likely to develop dementia with a crude hazard ratio of 0.617 (95% CI, 0.445-0.856, p = 0.004). After adjusting for age, gender, comorbidity, geographical area and urbanization level of residence, and monthly income, the adjusted hazard ratio was 0.517 (95% CI, 0.412-0.793, p = 0.001). CONCLUSIONS: The patients who used MgO had a decreased risk of developing dementia. Further studies on the effects of MgO in reducing the risk of dementia are therefore warranted.
    Date: 2018-01
    Relation: Current Medical Research and Opinion. 2018 Jan;34(1):163-169.
    Link to: http://dx.doi.org/10.1080/03007995.2017.1385449
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0300-7995&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000428725800019
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85032699927
    Appears in Collections:[Others] Periodical Articles

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