國家衛生研究院 NHRI:Item 3990099045/10786
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    题名: Trifunctional Fe3O4/CaP/Alginate core-shell-corona nanoparticles for magnetically guided, pH-responsive, and chemically targeted chemotherapy
    其它题名: Tri-functional Fe 3 O 4 /CaP/Alginate Core-Shell-Corona Nanoparticles for Magnetically Guided, pH-Responsive, and Chemically Targeted Chemotherapy
    作者: Wang, YP;Liao, YT;Liu, CH;Yu, J;Alamri, HR;Alothman, ZA;Hossain, MSA;Yamauchi, Y;Wu, KCW
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe3O4) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe3O4/CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe3O4/CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe3O4/CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems.
    日期: 2017-08-08
    關聯: ACS Biomaterials Science and Engineering. 2017 Aug 8;3(10):2366-2374.
    Link to: http://dx.doi.org/10.1021/acsbiomaterials.7b00230
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2373-9878&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000412866900017
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