國家衛生研究院 NHRI:Item 3990099045/10821
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10821


    Title: A mutation-resistant deoxyribozyme OR gate for highly selective detection of viral nucleic acids
    Authors: Kamar, O;Sun, SC;Lin, CH;Chung, WY;Lee, MS;Liao, YC;Kolpashchikov, DM;Chuang, MC
    Contributors: Institute of Population Health Sciences;National Institute of Infectious Diseases and Vaccinology
    Abstract: Highly selective probes hybridize only to fully complementary DNA or RNA sequences and, therefore, often fail to recognize mutated viral genomes. Here we designed a probe that possesses two seemingly incompatible properties: it tolerates some point mutations in genome, while it remains selective towards others. An OR deoxyribozyme logic gate was designed to fluorescently report the sequences of enterovirus 71 (EV71) covering similar to 90% of all known EV71 strains. Importantly, sequences of closely related coxsackieviruses that differed by single nucleotides were reliably differentiated in 7 out of 8 cases.
    Date: 2017-09
    Relation: Chemical Communications. 2017 Sep;53(76):10592-10595.
    Link to: http://dx.doi.org/10.1039/c7cc05576e
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1359-7345&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000411589300026
    Appears in Collections:[Yu-Chieh Liao] Periodical Articles
    [Min-Shi Lee] Periodical Articles

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