國家衛生研究院 NHRI:Item 3990099045/10849
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/10849


    Title: Restoration of polr1c in early embryogenesis rescues the Type 3 Treacher Collins Syndrome facial malformation phenotype in zebrafish
    Authors: Kwong, EML;Ho, JCH;Lau, MCC;You, MS;Jiang, YJ;Tse, WKF
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Treacher Collins Syndrome (TCS) is a rare congenital birth disorder (1 in 50,000 live births) characterized by severe craniofacial defects. Recently, our group unfolded the pathogenesis of polr1c Type 3 TCS by using the zebrafish model. Facial development depends on the neural crest cells, in which polr1c plays a role in regulating its expression. In this report, we aim to identify the functional time window of polr1c in TCS by the use of photo-morpholino to restore the polr1c expression at different time points. Results suggested that the restoration of polr1c at 8 hours post fertilization could rescue the TCS facial malformation phenotype by correcting the neural crest cell expression, reducing the cell death, and normalizing the p53 mRNA expression level in the rescued morphants. However, such recovery could not be reproduced if the polr1c is restored after 30 hours post fertilization.
    Date: 2018-02
    Relation: American Journal of Pathology. 2018 Feb;188(2):336-342.
    Link to: http://dx.doi.org/10.1016/j.ajpath.2017.10.004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0002-9440&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000423256300008
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85044281578
    Appears in Collections:[Yun-Jin Jiang] Periodical Articles

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