Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/10873
|
| Title: | Cognitive enhancers associated with decreased risk of injury in patients with dementia: A nationwide cohort study in Taiwan |
| Authors: | Chao, PC;Chien, WC;Chung, CH;Chu, CW;Yeh, CB;Huang, SY;Lu, RB;Chang, HA;Kao, YC;Yeh, HW;Chiang, WS;Chou, YC;Tzeng, NS |
| Contributors: | Center for Neuropsychiatric Research |
| Abstract: | This study aimed to investigate the associations among dementia, psychotropic medications and the risk of overall injuries. In this nationwide matched cohort study, a total of 144 008 enrolled patients >/=age of 50, with 36 002 study subjects who suffered from dementia and 108 006 controls matched for sex and age, from the Inpatient Dataset, for the period 2000-2010 in Taiwan were selected from the National Health Insurance Research Database, according to International Classification of Diseases, 9th Revision, Clinical Modification. When adjusting for the confounding factors, a Cox proportional hazards analysis was used to compare the risk of developing psychiatric disorders during the 10 years of follow-up. Of the study subjects, 6701 (18.61%) suffered injury when compared with 20 919 (19.37%) in the control group. The Cox regression analysis revealed that the study subjects were more likely to develop an injury (HR: 2.294, 95% CI=2.229 to 2.361, P<0.001) after adjusting for sex, age, monthly income, urbanization level, geographic region, and comorbidities. Psychotropic medications in the subjects with dementia were associated with the risk of injury (adjusted HR=0.217, 95% CI: 0.206 to 0.228, P<0.001). Cognitive enhancers, including acetylcholinesterase inhibitors and memantine, were associated with the risk of injury in the study subjects after being adjusted for all comorbidities and medications (adjusted HR=0.712(95% CI=0.512 to 0.925, P<0.01)). In conclusion, patients who suffered dementia had a higher risk of developing injury, and the cognitive enhancers were associated with the decreased risk of injury. |
| Date: | 2018-03 |
| Relation: | Journal of Investigative Medicine. 2018 Mar;66(3):684-692. |
| Link to: | http://dx.doi.org/10.1136/jim-2017-000595 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1081-5589&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000428916200007 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85042906391 |
| Appears in Collections: | [其他] 期刊論文
|
Files in This Item:
| File |
Size | Format | |
|---|
| PUB29141875.pdf | 1102Kb | Adobe PDF | 193 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
