國家衛生研究院 NHRI:Item 3990099045/10876
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    题名: Berberine activates Aryl Hydrocarbon Receptor but suppresses CYP1A1 induction through miR-21-3p stimulation in MCF-7 breast cancer cells
    作者: Lo, SN;Wang, CW;Chen, YS;Huang, CC;Wu, TS;Li, LA;Lee, IJ;Ueng, YF
    贡献者: National Institute of Environmental Health Sciences
    摘要: Berberine and the methylenedioxy ring-opening derivatives palmatine and jatrorrhizine are active ingredients in immunomodulatory plants, such as goldenseal. This study aimed to illustrate the effects of protoberberines on aryl hydrocarbon receptor (AhR) activation and cytochrome P450 (CYP) 1 in the estrogen receptor (ER)alpha(+) MCF-7 breast cancer cells. Among protoberberines at non-cytotoxic concentrations (</=10 muM), berberine had the most potent and statistically significant effects on AhR activation and CYP1A1/1A2/1B1 mRNA induction. The 24-h exposure to 10 muM berberine did not change CYP1A1 mRNA stability, protein level and function. Berberine significantly increased micro RNA (miR)-21-3p by 36% and the transfection of an inhibitor of miR-21-3p restored the induction of CYP1A1 protein with a 50% increase. These findings demonstrate that the ring opening of the methylenedioxyl moiety in berberine decreased AhR activation in MCF-7 cells. While CYP1A1 mRNA was elevated, berberine-induced miR-21-3p suppressed the increase of functional CYP1A1 protein expression.
    日期: 2017-10-28
    關聯: Molecules. 2017 Oct 28;22(11):Article number 1847.
    Link to: http://dx.doi.org/10.3390/molecules22111847
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1420-3049&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000416528400049
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85033785345
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