國家衛生研究院 NHRI:Item 3990099045/10926
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    题名: Trends in Carbapenemase-producing Klebsiella pneumoniae, Taiwan, 2012-2015
    作者: Chiu, SK;Ma, L;Chan, MC;Fung, CP;Wu, TL;Chuang, YC;Lu, PL;Wang, JT;Lin, JC;Yeh, KM
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Background: Before 2011, the prevalence rates of carbapenemaseproducing Klebsiella pneumoniae (CPKP) among carbapenem nonsusceptible K. pneumoniae (CnSKP) isolates were below 10% in Taiwan. We present the dissemination trends of CPKP from January 2012 to August 2015. Methods: Twenty-one hospitals in Taiwan were enrolled in the study. K. pneumoniae isolates with minimum inhibitory concentrations (MICs) of >1 mg/L for imipenem or meropenem were collected for carbapenemase genes screening and antimicrobial susceptibility testing. Results: A total of 1457 CnSKP isolates were collected and screened for carbapenemase genes, and tested for antimicrobial susceptibility. Among 457 CPKP isolates, three classes of carbapenemase genes were identified: class A (319 KPC-2, 2 KPC-3, 28 KPC-17, 2 KPC-25), class B (27 IMP-8, 38 VIM-1, 4 NDM-1), and class D (43 OXA-48). Among them, KPC-3, −17, −25, and OXA-48 were emerging during this period. The prevalence of CPKP increased from 24.1% in 2012 to 36.8% in 2015 and was as high as 70.3% in the west in 2015. Conclusion: This study depicts an ominous scenario of these highly resistant organisms, highlighting the enhanced infection control measures are required.
    日期: 2017-11
    關聯: International Journal of Antimicrobial Agents. 2017 Nov;50(Suppl. 2):S116.
    Link to: http://dx.doi.org/10.1016/S0924-8579(17)30423-5
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000416028900273
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