國家衛生研究院 NHRI:Item 3990099045/10927
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    题名: Acinetobacter calcoaceticus-A. baumannii complex, Taiwan
    作者: Lauderdale, TLY;Wang, HY;Shiau, YR;Lai, JF;Huanag, IW;Hospitals, STAR
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Background: A. calcoaceticus-A baumannii (ACB) complex comprises four genospecies: A. baumannii, A. calcoaceticus, A. nosocomialis, and A. pittii. Considerable differences exist in their epidemiology and clinical relevance but routine differentiation of these genospecies is not commonly done. The present study investigated the distribution and antimicrobial susceptibility of the ACB complex genospecies in the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program. Methods: Acinetobacter isolates were collected biennially as part of the TSAR program between 2010 and 2016 from 26 to 28 hospitals using the same collection protocols. Susceptibility to different antimicrobial agents was determined by broth microdilution in every study year but colistin was not tested in 2010. All ACB complex isolates were subjected to gyrB genospecies typing to differentiate the 4 species. Data from 2010 to 2012 were grouped together to compare with combined data of 2014 and 2016. Results: A total of 1321 ACB complex isolates were identified, including 337, 405, 290, and 289 isolates from 2010, 2012, 2014, and 2016, respectively. From 2010–2012 to 2014–2016, the proportion of A. baumannii decreased from 85.7 to 79.4% while that of A. nosocomialis increased from 4.4 to 11.2% (p < 0.001 for both), with A. pitti remaining stable at around 9%. The specimen distribution differed among A. baumannii, A. nosocomialis, and A. pitti isolates, with 55.1, 51.0, and 34.5%, respectively, from respiratory tract, and 13.9, 43.9, and 35.3%, respectively, from blood. Carbapenem nonsusceptibility in ACB complex was 64.6% in 2010–2012 and 59.9% in 2014–2016 overall (p = NS), but was significantly higher in A. baumannii (71.1%) than in A. nosocomialis (23.5%) and A. pitti (15.1%). Colistin resistance was not detected in 2012 and was 3.1% in 2014–2016 but no mcr-1 was detected. Conclusion: The prevalence of carbapenem resistance in A. baumannii remains very high in Taiwan. The changes in ACB complex genospecies distribution in recent years plus differences in their antimicrobial susceptibility and specimen distribution indicate the need for continued surveillance of this important group of pathogens.
    日期: 2017-11
    關聯: International Journal of Antimicrobial Agents. 2017 Nov;50(Suppl. 2):S113.
    Link to: http://dx.doi.org/10.1016/S0924-8579(17)30423-5
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000416028900266
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