國家衛生研究院 NHRI:Item 3990099045/10940

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Title:	TG/HDL-C ratio predicts development of albuminuria in type 2 diabetes with ACR < 10 mg/gm. A prospective cohort study
Authors:	Shin, SJ;Lin, KD;Lee, MY;Huang, MC;Yang, YC;Yang, HJ;Tai, TY;Kuo, KN;Hsu, CC
Contributors:	Institute of Population Health Sciences
Abstract:	Low normoalbuminuria (ACR < 10 mg/gm) is currently recognized as near normal renal function in type 2 diabetes. We hypothesized that TG/HDL-C ratio is the early biomarker to predict the development of DKD for type 2 diabetes. We enrolled 809 type 2 diabetic subjects with ACR < 30 mg/gm between 2003 and 2005 and followed them through the end of 2012. Among them, 518 subjects had ACR < 10 mg/gm. The average follow-up time was 6.2 years. The incidence rate ratio and Cox proportional hazards model were used to evaluate the association between baseline demographics and biochemical variables and development of albuminuria in 518 subjects with ACR < 10 mg/gm and 809 subjects with ACR < 30 mg/gm, respectively. Among 809 subjects with ACR < 30 mg/gm, 390 entered in albuminuric stage while 205 subjects developed albuminuria in 518 diabetes with ACR < 10 mg/gm. By using Cox proportional hazards model, we found that education, basal ACR and HOMA-IR in subjects with ACR < 30 mg/gm are independent predictors for development of albuminuria, whereas and education, basal ACR, and TG/HDL-C ratio are in subjects with ACR < 10 mg/gm. Compared with those in the lowest quartile of TG/HDH-C ratio, the multivariate HR for those in the 2nd, 3rd, and highest quartiles were 1.08 (95% CI 0.66–1.79), 1.38 (0.85–2.24), and 1.71 (1.03–2.82), respectively (trend test: P < 0.015) in diabetes p with ACR < 10 mg/gm. According to the dose-response effects of TG/HDL-C ratio shown in this prospective study, we conclude that TG/HDL-C ratio could be an early predictor for development of albuminuria in type 2 diabetes.
Date:	2016-10
Relation:	Diabetes Research and Clinical Practice. 2016 Oct;120(Suppl. 1):S148.
Link to:	http://dx.doi.org/10.1016/S0168-8227(16)31307-9
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0168-8227&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000416113300437
Appears in Collections:	[Ken-Nan Kuo] Conference Papers/Meeting Abstract [Chih-Cheng Hsu] Conference Papers/Meeting Abstract

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