國家衛生研究院 NHRI:Item 3990099045/10955
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    题名: Indeno 1,2,3-cd pyrene, a common environmental polycyclic aromatic hydrocarbon, enhances allergic lung inflammation via aryl hydrocarbon receptor
    作者: Wong, TH;Lee, CL;Su, HH;Huang, SK;Suen, JL
    贡献者: National Institute of Environmental Health Sciences
    摘要: Background: Chronic exposure to ambient polycyclic aromatic hydrocarbons (PAHs) is associated with asthma. Objectives: We aimed to identify the main component of ambient PAHs in southern Taiwan and elucidate their role in allergic asthma. Methods: One-year air samplings with measurement of 16 PAHs were performed. A mouse model of pulmonary allergic inflammation and its associated parameters were analyzed by established methods. Results: Indeno[1,2,3-cd]pyrene (IP) was found to be a prominent PAH associated with ambient PM2.5 in a subtropical industrial city in Taiwan. IP exposure at the concentration ranging from 0.4 to 2 μM significantly enhanced antigen-induced allergic inflammation, including increased eosinophil infiltration, IL-4/IL-5 production and antigen-specific IgE level, which could be blocked by the addition of an AhR antagonist, CH223191, and was absent in dendritic cell (DC)-specific AhR-null mice. Mechanistically, IP treatment significantly altered DC’s function in vitro, including increased level of proinflammatory IL-6 secretion and decreased generation of antiinflammatory IL-10. The IP’s effect was lost in DCs from mice carrying an AhR-mutant allele (AhRd). Conclusion: Chronic exposure to IP, a prominent ambient PAH in southern Taiwan, enhanced the severity of allergic lung inflammation in mice through, at least in part, its ability in modulating the DC’s function in an AhR-dependent manner.
    日期: 2017-12
    關聯: Cytokine. 2017 Dec;100(SI):134.
    Link to: https://doi.org/10.1016/j.cyto.2017.09.011
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1043-4666&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000414817600388
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