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| 題名: | Altered pattern of monocyte differentiation and monocyte-derived TGF-beta1 in severe asthma |
| 其他題名: | Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma |
| 作者: | Hung, CH;Wang, CC;Suen, JL;Sheu, CC;Kuo, CH;Liao, WT;Yang, YH;Wu, CC;Leung, SY;Lai, RS;Lin, CC;Wei, YF;Lee, CY;Huang, MS;Huang, SK |
| 貢獻者: | National Institute of Environmental Health Sciences |
| 摘要: | CD14(+) monocytes contain precursors for macrophages and fibrocytes, known to be involved in regulating airway remodeling in human asthma and distinguishable by the PM-2K marker. We sought to identify circulating subsets of PM-2K(+) macrophage-like cells and evaluate their relationships to lung function, severity and control status. Circulating PM-2K(+) macrophage-like cells and fibrocytes could be identified and distinguished between normal individuals (N = 152) and asthmatic subjects (N = 133) using multi-parametric flow cytometry. PM-2K(+) macrophage-like cells were found to be significantly lower in asthmatic subjects, particularly noted for the CD14(-)PM-2K(+) subset and PM-2K(+)CCR7(-)CD86(+) cells in subjects with poor lung function (FEV%/FVC% < 80%) as compared to those of normal subjects and asthmatics with normal lung function, whereas the frequency of fibrocytes was higher in asthmatics and the CCR7(-)CD86(+) subset distribution was significantly different in subjects with varying severity. Moreover, exogenous transforming growth factor beta 1 (TGF-beta1) was found to inhibit the generation of PM-2K(+) macrophage(-)like cells, but promote the growth of fibrocytes, from CD14(+) monocytes(,) and monocyte-derived TGF-beta1 was found to correlate with the lung function, severity and control status in asthmatic patients. Collectively, aberrant differentiation of monocytes into PM-2K(+) macrophage-like cell subsets and fibrocytes, together with increased monocyte-derived TGF-beta1, characterized patients with severe asthma. |
| 日期: | 2018-01-17 |
| 關聯: | Scientific Reports. 2018 Jan 17;8:Article number 919. |
| Link to: | http://dx.doi.org/10.1038/s41598-017-19105-z |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000422716900053 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85041618798 |
| 顯示於類別: | [黃嘯谷] 期刊論文
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