國家衛生研究院 NHRI:Item 3990099045/11007
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    题名: Similar but not the same, the fission yeast processing bodies
    作者: Wang, SW
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Processing bodies (P-bodies) are cytoplasmic RNA granules containing the Dcp1-Dcp2 decapping-enzymes where mRNA decay can occur. We have used the fission yeast Schizosaccharomyces pombe as a model system to study their structures and compositions. Because several components of P-bodies, such as the decapping enzyme and its co-activators, are found in both yeast and mammalian cells, it is believed that P-bodies are evolutionarily conserved among eukaryotes. However, we found that species diversity has developed; the protein compositions and underlying molecular mechanisms for their function can be distinct between species. These results led us to suggest that the whole complex including the decapping-enzyme and its co activators might have coevolved together and acquired additional proteins and different mechanisms for its function highlighting the importance of cross-pecies studies of this sort. Furthermore, we found that, although predominantly present in the cytoplasm, components of P-bodies also function in the nucleus. A function of Pdc2, the fission yeast ortholog of Pat1 protein, and the decapping enzyme Dcp1-cp2 function together with the 5’-3’ exonuclease Dhp1 in the nucleus to regulate lncRNA by promoting its decapping/destruction was suggested.
    日期: 2018-01
    關聯: International Journal of Molecular Biology: Open Access. 2018 Jan 17;31(1):Article number 00041.
    Link to: http://dx.doi.org/10.15406/ijmboa.2018.03.00041
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