國家衛生研究院 NHRI:Item 3990099045/11017
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    题名: KDM4C: A novel oncogene and prognostic biomarker for prostate cancer
    作者: Chuu, CP;Lin, CY;Wang, BJ
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Human histone lysine demethylases 4C is an AR co-regulator. We investigated the role of KDM4C in prostate cancer (PCa). Analysis of both Oncomine gene datasets and commercial tissues array, we observed that the mRNA and protein expression of KDM4C is highest in metastatic prostate cancer tissues. PCa patients with higher KDM4C expression level correlate to worse prognosis. Knockdown of KDM4C in PCa cells reduced cell proliferation, soft agar colony formation, migration, and invasion as well as suppressed tumor growth in PCa orthotopic model in nude mice. Prostate cancer stem cells and docetaxel resistant PCa cells express higher KDM4C proteins. Micro Western Array (MWA) is an antibody-based high throughput protein array allowing detecting protein expression level or phosphorylation status change of 96-192 different antibodies in 6 to 15 samples simultaneously. MWA analysis indicated that reduction of KDM4C affected protein expression of cell cycle regulatory proteins, cMyc, DKK3, and EMT marker proteins. Our study indicated that KDM4C is a novel oncogene in PCa and KDM4C may serve as a prognostic biomarker for clinical outcome of PCa.
    日期: 2018-01
    關聯: Cancer Science. 2018 Jan;109(Suppl. 1):1073.
    Link to: http://dx.doi.org/10.1111/cas.13499
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000422694006186
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