國家衛生研究院 NHRI:Item 3990099045/11018

NHRI > Institute of Cellular and Systems Medicine > Chih-Pin Chuu > Conference Papers/Meeting Abstract > Item 3990099045/11018

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11018

Title:	Role of ACTL6A in human prostate cancer cell
Authors:	Huang, SH;Lin, CY;Chuu, CP
Contributors:	Institute of Cellular and Systems Medicine
Abstract:	Prostate cancer (PCa) incidence is the 2nd most common male cancer overall in the world. PCa is the 6th most common cancer in Taiwan. Actin-like protein 6A (ACTL6A) gene encodes a family member of actin-related proteins (ARPs), which are involved in vesicular transport, spindle orientation, nuclear migration and chromatin remodeling in cells. We compare the correlation between ACTL6A and serum prostate specific antigen (PSA). We observed that high IHC staining level of ACTL6A correlated to high serum PSA and high prostate cancer recurrence rate in PCa patients. PC-3 is PCa cell lines generated from bone metastatic PCa cells. Knockdown of ACTL6A by shRNA in PC-3 cells suppressed proliferation, migration, and invasion. Micro-Western Array analysis indicated that knock down of ACTL6A affected proteins involved in epithelial-mesenchymal transition (EMT). Orthotopic nude mice PCa model with IVIS imaging revealed that knockdown of ACTL6A reduced PCa metastasis. Our result suggested that ACTL6A is a novel oncogene for PCa and may serve as a prognostic marker for advanced PCa.
Date:	2018-01
Relation:	Cancer Science. 2018 Jan;109(Suppl. 1):1074.
Link to:	http://dx.doi.org/10.1111/cas.13499
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000422694006188
Appears in Collections:	[Chih-Pin Chuu] Conference Papers/Meeting Abstract

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