國家衛生研究院 NHRI:Item 3990099045/11023
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11023


    Title: Allergic conjunctivitis-induced retinal inflammation promotes myopia progression
    Authors: Wei, CC;Kung, YJ;Chen, CS;Chang, CY;Lin, CJ;Tien, PT;Chang, HY;Chen, HJ;Huang, YS;Lin, HJ;Wan, L
    Contributors: Institute of Population Health Sciences
    Abstract: Myopia is a highly prevalent eye disease. There is limited information suggesting a relationship between myopia and inflammation. We found children with allergic conjunctivitis (AC) had the highest adjusted odds ratio (1.75, 95% confidence interval [CI], 1.72-1.77) for myopia among the four allergic diseases. A cohort study was conducted and confirmed that children with AC had a higher incidence and subsequent risk of myopia (hazard ratio 2.35, 95%CI 2.29-2.40) compared to those without AC. Lower refractive error and longer axial length were observed in an AC animal model. Myopia progression was enhanced by tumor necrosis factor (TNF)-alpha or interleukin (IL)-6 administration, two cytokines secreted by mast cell degranulation. The TNF-alpha or IL-6 weakened the tight junction formed by corneal epithelial (CEP) cells and inflammatory cytokines across the layer of CEP cells, which increased the levels of TNF-alpha, IL-6, and IL-8 secreted by retinal pigment epithelial cells. The expression levels of TNF-alpha, IL-6, IL-8, monocyte chemoattractant protein-1, and nuclear factor kappa B were up-regulated in eyes with AC, whereas IL-10 and the inhibitor of kappa B were down-regulated. In conclusion, the experimental findings in mice corroborate the epidemiological data showing that allergic inflammation influences the development of myopia.
    Date: 2018-02
    Relation: EBioMedicine. 2018 Feb;28:274-286.
    Link to: http://dx.doi.org/10.1016/j.ebiom.2018.01.024
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2352-3964&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000425875600039
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85041599338
    Appears in Collections:[Hsing-Yi Chang] Periodical Articles

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