國家衛生研究院 NHRI:Item 3990099045/11031
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    题名: Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy
    作者: Liu, X;Hong, X;Tsai, HJ;Mestan, KK;Shi, M;Kefi, A;Hao, K;Chen, Q;Wang, G;Caruso, D;Geng, H;Gao, Y;He, J;Kumar, R;Wang, H;Yu, Y;Bartell, T;Tan, XD;Schleimer, RP;Weeks, DE;Pongracic, JA;Wang, X
    贡献者: Institute of Population Health Sciences
    摘要: Previous genetic studies of food allergy (FA) have mainly focused on inherited genotypic effects. The role of parental genotypic effects remains largely unexplored. Leveraging existing genome-wide association study (GWAS) data generated from the Chicago Food Allergy Study, we examined maternal genotypic and parent-of-origin (PO) effects using multinomial likelihood ratio tests in 588 complete and incomplete Caucasian FA trios. We identified 1 single nucleotide polymorphism with significant (P < 5x10) maternal effect on any FA (rs4235235), which is located in a noncoding RNA (LOC101927947) with unknown function. We also identified 3 suggestive (P < 5x10) loci with maternal genetic effects: 1 for any FA (rs976078, in a gene desert region on 13q31.1) and 2 for egg allergy (rs1343795 and rs4572450, in the ZNF652 gene, where genetic variants have been associated with atopic dermatitis). Three suggestive loci with PO effect were observed: 1 for peanut allergy (rs4896888 in the ADGB gene) and 2 for any FA in boys only (rs1036504 and rs2917750 in the IQCE gene). Findings from this family-based GWAS of FA provided some preliminary evidence on maternal genotypic or PO effects on FA. Additional family-based studies are needed to confirm our findings and gain new insight into maternal and paternal genetic contribution to FA.
    日期: 2018-03
    關聯: Medicine. 2018 Mar;97(9):Article number e0043.
    Link to: http://dx.doi.org/10.1097/md.0000000000010043
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0025-7974&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000427995800016
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85042748351
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