國家衛生研究院 NHRI:Item 3990099045/11075
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    題名: Pre-treatment with either L-carnitine or piracetam increases ultrasound-mediated gene transfection by reducing sonoporation-associated apoptosis
    作者: Liao, WH;Wu, CH;Chen, WS
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Sonoporation, the use of ultrasound to alter the permeability of cell membranes, is a non-viral technique used to facilitate gene delivery, possibly by opening transient pores in the cell membrane. However, sonoporation may have negative bio-effects on cells, such as causing apoptosis, which limits its efficacy in gene delivery. In this study, we investigated whether pre-treatment with either L-carnitine or piracetam could protect cells from undergoing apoptosis after sonoporation and the possible mechanisms. We found that either L-carnitine or piracetam can promote gene transfection without reducing cell viability, possibly by reducing cavitation-induced reactive oxygen species generation, reversing alterations of mitochondrial membrane potential, preventing caspase-3/7 activity and facilitating mitochondrial ATP production. In conclusion, pre-treatment with either L-carnitine or piracetam could protect cells from sonoporation-associated apoptosis by preserving mitochondrial function.
    日期: 2018-06
    關聯: Ultrasound in Medicine and Biology. 2018 Jun;44(1257-1265):1257-1265.
    Link to: http://dx.doi.org/10.1016/j.ultrasmedbio.2018.02.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0301-5629&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000430322800012
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85043513346
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