國家衛生研究院 NHRI:Item 3990099045/11091
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 915106      在线人数 : 1348
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11091


    题名: Association between nonsteroidal anti-inflammatory drugs and atrial fibrillation among a middle-aged population: A nationwide population-based cohort
    作者: Chuang, SY;Hsu, PF;Lin, FJ;Huang, YW;Wang, GZ;Chang, WC;Tsai, HJ
    贡献者: Institute of Population Health Sciences
    摘要: AIMS: It remains inconclusive whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of atrial fibrillation (AF), especially in middle-aged Asian populations. In this study, we evaluated the association between NSAID use and the risk of AF in a nationwide population-based study of middle-aged individuals in Taiwan. METHODS: A nested case-control study was conducted using the National Health Insurance Research Database (NHIRD) in Taiwan. We identified the cases with a diagnosis of AF (ICD-9-CM codes: 427.31) and the matched controls from three independent Longitudinal Health Insurance Databases (LHIDs) derived from the NHIRD from data collected from 2001 to 2013. Conditional logistic regression models with covariates adjustment were performed to evaluate the association between NSAID use and the risk of AF. RESULTS: A total of 57,058 participants (28,529 AF cases and 28,529 matched controls) were included. Participants with NSAID use had an elevated risk of AF compared to non-users (adjusted odds ratio (AOR)=1.18, 95% confidence interval (CI): 1.14-1.23). When further assessing the effects of different classes of NSAIDs on the risk of AF, the results showed that participants who used non-selective NSAIDs had a significantly elevated risk of AF (AOR=1.18, 95%CI: 1.13-1.23), as did participants with a combined use of selective and non-selective NSAIDs (AOR=1.30, 95%CI: 1.21-1.39). CONCLUSIONS: NSAID use was associated with an increased risk of AF occurrence among the participants included in our study cohort. Closely monitoring the adverse effects of NSAID treatment on the risk of AF will be important, particularly among individuals at high risk.
    日期: 2018-06
    關聯: British Journal of Clinical Pharmacology. 2018 Jun;84(6):1290-1300.
    Link to: http://dx.doi.org/10.1111/bcp.13558
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0306-5251&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000434063100020
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85044724423
    显示于类别:[蔡慧如] 期刊論文
    [莊紹源] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    PUB29560612.pdf760KbAdobe PDF298检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈