國家衛生研究院 NHRI:Item 3990099045/11108
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    题名: Stress resistance and lifespan enhanced by downregulation of antimicrobial peptide genes in the Imd pathway
    作者: Lin, YR;Parikh, H;Park, Y
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18 degrees C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25 degrees C. Gene expression analysis between the flies developed at 18 degrees C and 25 degrees C revealed that the Immune deficiency (Imd) pathway, including the downstream antimicrobial peptides (AMPs), is downregulated in the flies developed at 18 degrees C. When hypomorphic imd mutant flies with reduced AMP expressions were developed at 25 degrees C, they showed induced stress resistance with higher fat content in the body similar to the wild-type flies developed at 18 degrees C. However, severe hypomorphic imd mutants could not enhance stress resistance due to the downregulation of another downstream JNK pathway that expresses stress tolerance genes. Interestingly, the downregulation of AMP genes, itself, extended lifespan with increased stress resistance. Especially, fat body-specific downregulation of Imd AMP genes exhibited a longer lifespan with higher heat resistance. The fat body is known to function in metabolic homeostasis, stress tolerance, growth, and longevity in Drosophila. Here, we provide the first evidence that mild downregulation of the Imd pathway with AMP genes increases fat content, stress resistance, and lifespan in adult flies.
    日期: 2018-04
    關聯: Aging. 2018 Apr 19;10(4):622-631.
    Link to: http://dx.doi.org/10.18632/aging.101417
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1945-4589&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000433595400015
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85046880601
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