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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/11126
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| Title: | Study design and recruitment for a prospective controlled study of diabesity: Taiwan diabesity study |
| Authors: | Lee, WJ;Chang, YC;Almalki, O;Chao, SH;Lu, CH;Chen, CC;Huang, YY;Lee, YC;Hsu, CC |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Background: Strong evidence has shown that metabolic surgery is more effective than medical treatment in the treatment of type 2 diabetic patients. However, no study demonstrated a survival benefit and reduction of diabetes-related end-organ damage. Here, we describe the study design of a large prospective cohort study, the Taiwan Diabesity Study (TDS) which would compare the long-term survival rate and end-organ damage between overweight/obese type 2 diabetic patients receiving metabolic surgery and medical treatment. Methods: Eligibility criteria include type 2 diabetic patients with duration > 6 months, body mass index (BMI) over 25 kg/m2 and age between 20 and 67 years. Exclusion criteria are serum creatinine over 2.0 mg/dL, C-peptide below 1.0 ng/ml, recent history of cancer, and major diabetic complications. Eligible participants were recruited from six medical centers in Taiwan. The survival rate and diabetes-related end organ damage will be compared between the metabolic surgery group and medical group after follow-up for 10 years. Results: In 3 years, 1016 participants were identified from 38,751 patients. The average BMI of patients was 30.6 (±2.6) kg/m2 and the average hemoglobin A1c was 8.2% (±1.5%) with 18% of them receiving insulin treatment. Among them, 126 patients received metabolic surgery and 890 patients received conventional medical treatment. The metabolic surgery group are younger, have a higher proportion of females, higher BMI and blood lipids as compared to the medical group. Conclusion: The TDS recruited 1016 overweight/obese type 2 diabetic patients including 126 patients receiving metabolic surgery and 890 patients receiving medical treatment. |
| Date: | 2018-04-06 |
| Relation: | Asian Journal of Surgery. 2019 Jan 1;42(1):244-250. |
| Link to: | http://dx.doi.org/10.1016/j.asjsur.2018.02.007 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1015-9584&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000454143100034 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85045001937 |
| Appears in Collections: | [許志成] 期刊論文
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| SCP85045001937.pdf | | 428Kb | Adobe PDF | 236 | View/Open |
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