國家衛生研究院 NHRI:Item 3990099045/11130

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Title:	Early life weight gain and development of childhood asthma in a prospective birth cohort
Authors:	Tsai, HJ;Wang, GY;Hong, XM;Ji, YL;Wang, XB
Contributors:	Institute of Population Health Sciences
Abstract:	RATIONALE: Childhood asthma has been on the rise in the U.S. and worldwide. In parallel, the obesity epidemic continues to affect all age groups, including pregnant women and their children. While obesity and asthma are associated, it remains unclear which one comes ﬁrst. We sought to investigate whether early life weight gain can affect the risk of childhood asthma in the Boston Birth Cohort. METHODS: This report included 1,971 children (550 asthmatic) enrolled at birth and followed up to age 16 years. We categorized the children by their weight gain Z -score during the ﬁrst 4, 12 and 24 months of life, respectively, into four groups: slow ( <2 0.67), on track ( 2 0.67-0.67), rapid (0.67-1.28), and extremely rapid growth ( > 1.28). Logistic regressions were applied to determine the relationship between weight gain and childhood asthma. RESULTS: Weight gain in the ﬁrst 4, 12, and 24 months was all signiﬁcantly associated with an increased risk of childhood asthma. Using 12 month as an example, an adjusted odds ratio (AOR) of 1.6 and a 95% conﬁdence interval (CI) of 1.1-2.2 were found for the extremely rapid growth group compared to the on-track group. The association was more pronounced among children born preterm (AOR 5 5.3; 95%CI 5 1.815.7). CONCLUSIONS: In this predominantly urban, low-income minority birth cohort, excessive weight gain in the ﬁrst 4, 12, and 24 months, was all associated with an increased risk of childhood asthma, particularly among those with preterm birth. This ﬁnding underscores the importance of ensuring optimal weight gain in infancy for reducing the risk of childhood asthma.
Date:	2018-02
Relation:	Journal of Allergy and Clinical Immunology. 2018 Feb;141(2, Suppl.):AB194.
Link to:	https://doi.org/10.1016/j.jaci.2017.12.614
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0091-6749&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000429306700609
Appears in Collections:	[Hui-Ju Tsai] Conference Papers/Meeting Abstract

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