國家衛生研究院 NHRI:Item 3990099045/11132

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Title:	Effect of birth weight on lung function and exhaled nitric oxide in a cohort of Asian children at six years of age
Authors:	Lee, WF;Gau, CC;Lu, IC;Lin, LL;Wu, CY;Tsai, HJ;Yao, TC
Contributors:	Institute of Population Health Sciences
Abstract:	RATIONALE: Although low birth weight has been linked to reduced lung function in children in previous studies, there is a paucity of research in this area among Asian populations. Our aim was to evaluate how birth weight affects lung function measurements and fraction of exhaled nitric oxide (FeNO) in Asian children. METHODS: We used data for 385 Asian children (201 boys, 54.5%) from the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort to determine the association of birth weight with lung function parameters and FeNO levels at 6 years of age, adjusted for gestation age, sex, age, current height, maternal smoking during pregnancy, and maternal asthma. RESULTS: Birth weight was signiﬁcantly positively associated with forced vital capacity (FVC) (p 5 0.026), forced expiratory volume in 1 second (FEV 1 ) (p 5 0.025), peak expiratory ﬂow (PEF) (p 5 0.029), and forced expiratory ﬂow at 25-75% (FEF 25-75 ) (p 5 0.042), but not with the FEV 1 /FVC ratio (p 5 0.508), after adjusting for confounders. In subgroup analysis stratiﬁed by physiciandiagnosed asthma, birth weight was positively associated with FVC, FEV 1 , and PEF in children without asthma, but not in children with asthma. A consistent pattern of association between birth weight and post-bronchodilator lung function parameters was observed. There was no signiﬁcant association between birth weight and FeNO levels, after adjusting for confounders. CONCLUSIONS: Birth weight is signiﬁcantly associated with lung function in this cohort of Asian children at school age, while the effect is mostly conﬁned to children without asthma. Birth weight has no obvious effect on FeNO levels in Asian schoolchildren.
Date:	2018-02
Relation:	Journal of Allergy and Clinical Immunology. 2018 Feb;141(2, Suppl.):AB5.
Link to:	https://doi.org/10.1016/j.jaci.2017.12.016
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0091-6749&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000429306700015
Appears in Collections:	[Hui-Ju Tsai] Conference Papers/Meeting Abstract

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