國家衛生研究院 NHRI:Item 3990099045/11135
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    题名: Add-on memantine treatment for bipolar II disorder comorbid with alcohol dependence: A 12-week follow-up study
    作者: Lee, SY;Wang, TY;Chen, SL;Chang, YH;Chen, PS;Huang, SY;Tzeng, NS;Wang, LJ;Lee, IH;Chen, KC;Yang, YK;Hong, JS;Lu, RB
    贡献者: Center for Neuropsychiatric Research
    摘要: BACKGROUND: Bipolar disorder (BD), especially BD-II, is frequently comorbid with alcohol dependence. Because BD-II and alcohol dependence are neurodegenerative disorders, agents with anti-inflammatory and neurotrophic effects might provide effective therapy. We investigated whether add-on memantine to regular valproate (VPA) treatment ameliorated clinical symptoms, reduced alcohol use and cytokine levels, and increased plasma brain-derived neurotrophic factor (BDNF) in BD-II patients with comorbid alcohol dependence. METHOD: In a single-arm 12-week clinical trial, BD-II patients with comorbid alcohol dependence (n=45) undergoing regular VPA treatments were given add-on memantine (5 mg/day). Symptom severity, alcohol use, cytokine (plasma tumor necrosis factor [TNF]-alpha and C-reactive protein [CRP], transforming growth factor beta1 [TGF-beta1], interleukin-8 [IL-8], IL-10), and plasma BDNF levels were regularly assessed. RESULTS: Mean within-group decreases in Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) scores, alcohol use, CRP, BDNF, and IL-8 levels were significantly different from baseline after 12 weeks of treatment. We found no significant correlation between alcohol use levels and changes in HDRS or YMRS scores. The correlation between reduced alcohol use and reduced TGF-beta1 level was significant (B = 0.003, p = 0.019). CONCLUSIONS AND RELEVANCE: BD-II comorbid with alcohol dependence might benefit from add-on memantine treatment, which significantly reduced clinical severity, alcohol use, and plasma cytokine levels, and increased BDNF levels.
    日期: 2018-06
    關聯: Alcoholism, Clinical and Experimental Research. 2018 Jun;42(6):1044-1050.
    Link to: http://dx.doi.org/10.1111/acer.13640
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000434037300007
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85047479278
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