國家衛生研究院 NHRI:Item 3990099045/1114

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1114

Title:	Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis
Authors:	Wu, PL;Lin, FW;Wu, TS;Kuoh, CS;Lee, KH;Lee, SJ
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Three new compounds: begonanline (1), nantoamide (2) and methyl (S)-glycerate (3) as well as forty-four known compounds have been isolated and characterized from the rhizomes of Begonia nantoensis. The structures of these compounds were determined by spectral analyses and/or X-ray crystallography. Among them, cucurbitacin B (4), dihydrocucurbitacin B (5), cucurbitacin E (6), dihydrocucurbitacin E (7), cucurbitacin 1 (8), and (-)-auranamide (9) showed cytotoxicity against four human cancer cell lines. 3beta,22alpha-Dihydroxyolean-12-en-29-oic acid (10), indole-3-carboxylic acid (11), 5,7-dihydroxychromone (12), and (-)-catechin (13) demonstrated significant activity against HIV replication in H9 lymphocyte cells.
Keywords:	Chemistry, Medicinal;Chemistry, Multidisciplinary;Pharmacology & Pharmacy
Date:	2004-03
Relation:	Chemical and Pharmaceutical Bulletin. 2004 Mar;52(3):345-349.
Link to:	http://dx.doi.org/10.1248/cpb.52.345
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-2363&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000220026000011
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=4544340410
Appears in Collections:	[Shiow-Ju Lee] Periodical Articles

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