國家衛生研究院 NHRI:Item 3990099045/11152
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11152


    Title: Wild-type p53 upregulates an early onset breast cancer-associated gene GAS7 to suppress metastasis via GAS7-CYFIP1-mediated signaling pathway
    Authors: Chang, JW;Kuo, WH;Lin, CM;Chen, WL;Chan, SH;Chiu, MF;Chang, IS;Jiang, SS;Tsai, FY;Chen, CH;Huang, PH;Chang, KJ;Lin, KT;Lin, SC;Wang, MY;Uen, YH;Tu, CW;Hou, MF;Tsai, SF;Shen, CY;Tung, SL;Wang, LH
    Contributors: Institute of Molecular and Genomic Medicine;National Institute of Cancer Research
    Abstract: The early onset breast cancer patients (age </= 40) often display higher incidence of axillary lymph node metastasis, and poorer five-year survival than the late-onset patients. To identify the genes and molecules associated with poor prognosis of early onset breast cancer, we examined gene expression profiles from paired breast normal/tumor tissues, and coupled with Gene Ontology and public data base analysis. Our data showed that the expression of GAS7b gene was lower in the early onset breast cancer patients as compared to the elder patients. We found that GAS7 was associated with CYFIP1 and WAVE2 complex to suppress breast cancer metastasis via blocking CYFIP1 and Rac1 protein interaction, actin polymerization, and beta1-integrin/FAK/Src signaling. We further demonstrated that p53 directly regulated GAS7 gene expression, which was inversely correlated with p53 mutations in breast cancer specimens. Our study uncover a novel regulatory mechanism of p53 in early onset breast cancer progression through GAS7-CYFIP1-mediated signaling pathways.
    Date: 2018-07
    Relation: Oncogene. 2018 Jul;37(30):4137-4150.
    Link to: http://dx.doi.org/10.1038/s41388-018-0253-9
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0950-9232&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000439847000007
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85046096573
    Appears in Collections:[Lu-Hai Wang] Periodical Articles
    [Shih-Feng Tsai] Periodical Articles
    [Shih-Sheng Jiang] Periodical Articles
    [I-Shou Chang] Periodical Articles

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