國家衛生研究院 NHRI:Item 3990099045/11165
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12340/13512 (91%)
造访人次 : 2256860      在线人数 : 298
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/11165


    题名: Human Kinase/Phosphatase-Wide RNAi screening identified checkpoint kinase 2 as a cellular factor facilitating Japanese encephalitis virus infection
    作者: Chan, YL;Liao, CL;Lin, YL
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, causes acute encephalitis in humans with high mortality. Not much is known about the interactions between viral and cellular factors that regulate JEV infection. By using a kinase/phosphatase-wide RNAi screening approach, we identified a cell cycle-regulating molecule, checkpoint kinase 2 (CHK2), that plays a role in regulating JEV replication. JEV infection induced G1 arrest and activated CHK2. Inactivation of CHK2 and its upstream ataxia-telangiectasia mutated kinase in JEV-infected cells by using inhibitors reduced virus replication. Likewise, JEV replication was significantly decreased by knockdown of CHK2 expression with shRNA-producing lentiviral transduction. We identified CHK2 as a cellular factor participating in JEV replication, for a new strategy in addressing JEV infection.
    日期: 2018-05-17
    關聯: Frontiers in Cellular and Infection Microbiology. 2018 May 17;8:Article number 142.
    Link to: http://dx.doi.org/10.3389/fcimb.2018.00142
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2235-2988&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000432398600001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85047159280
    显示于类别:[廖經倫] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000432398600001.pdf1865KbAdobe PDF336检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈