國家衛生研究院 NHRI:Item 3990099045/11167
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    題名: Liver regeneration accelerates hepatitis B virus‐related tumorigenesis of hepatocellular carcinoma
    作者: Teng, CF;Chang, HY;Tsai, HW;Hsieh, WC;Kuo, YH;Su, IJ;Lin, YJ
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: Although partial hepatectomy (PH) to remove tumors provides a potential cure of hepatocellular carcinoma (HCC), long-term survival of hepatitis B virus (HBV)-related HCC patients after PH remains a big challenge. Early recurrence within two years post-PH is associated with the dissemination of primary HCC. However, late recurrence after two years post-PH is supposed due to the de novo or a secondary tumor. Since PH initiates liver regeneration (LR), we hypothesize that LR may accelerate tumorigenesis through activation of pre-existing precancerous lesions in the remaining liver. In this study, we explored the potential role of several LR-related factors in the de novo recurrence in a HBV X protein (HBx) transgenic mouse model receiving PH to mimic human HCC development. Following PH, we observed that tumor development was significantly accelerated from 16.9 to 10.4 months in HBx transgenic mice. The expression of suppressor of cytokine signaling (SOCS) family proteins was remarkably suppressed in livers of HBx transgenic relative to non-transgenic mice from early to late stages after PH as compared with non-PH mice. The expression of TGF-beta/Smad pathway, HGF, Myc, STAT3, and beta-Catenin also showed significant difference between livers of HBx transgenic and non-transgenic mice at variable time points after PH in comparison with non-PH mice. Taken together, our results provide an explanation for the high de novo recurrence of HBV-related HCC after PH, probably through induction of the sequential changes of LR-related SOCS family proteins, growth factors, and transcription factors, which may promote growth on the precancerous remnant liver.
    日期: 2018-07
    關聯: Molecular Oncology. 2018 Jul;12(7):1175-1187.
    Link to: http://dx.doi.org/10.1002/1878-0261.12318
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1574-7891&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000436942300012
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85047665072
    顯示於類別:[蘇益仁(2002-2015)] 期刊論文

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