國家衛生研究院 NHRI:Item 3990099045/11208

NHRI > Institute of Biotechnology and Pharmaceutical Research > Kak-Shan Shia > Periodical Articles > Item 3990099045/11208

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11208

Title:	Total synthesis of tetarimycin A, (±)-Naphthacemycin A9, and (±)-Fasamycin A: structure-activity relationship studies against drug-resistant bacteria
Authors:	Huang, JK;Yang Lauderdale, TL;Lin, CC;Shia, KS
Contributors:	Institute of Biotechnology and Pharmaceutical Research
Abstract:	Making use of a reductive olefin coupling reaction and Michael-Dieckmann condensation as two key operations, we have completed a concise total synthesis of tetarimycin A, (±)-naphthacemycin A9, and (±)-fasamycin A in a highly convergent and practical protocol. Synthetic procedures thus developed have also been applied to provide related analogues for structure-activity relationship studies, thereby coming to the conclusion that the free hydroxyl group at C-10 is essential for exerting inhibitory activities against a panel of Gram-positive bacteria, including drug-resistant strains VRE and MRSA.
Date:	2018-05-22
Relation:	Journal of Organic Chemistry. 2018 May 22;83(12):6508-6523.
Link to:	http://dx.doi.org/10.1021/acs.joc.8b00802
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3263&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000445712900024
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85047456786
Appears in Collections:	[Kak-Shan Shia] Periodical Articles

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