國家衛生研究院 NHRI:Item 3990099045/11249
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    题名: Paradoxical relationship between glycated hemoglobin and longitudinal change in physical functioning in older adults: A prospective cohort study
    作者: Wu, IC;Hsu, CC;Chen, CY;Chuang, SC;Cheng, CW;Hsieh, WS;Wu, MS;Liu, YT;Liu, YH;Tsai, TL;Lin, CC;Hsiung, CA
    贡献者: Institute of Population Health Sciences
    摘要: Background: Hyperglycemia with high hemoglobin A1c (HbA1c) levels is associated with significant health risks. However, the relationship between HbA1c levels and the physical functioning status in later life remains uncertain and so is the possible underlying mechanism. Methods: We conducted a prospective study of 2,565 initially well-functioning community-dwelling older adult aged 55 years and older from the Healthy Aging Longitudinal Study in Taiwan. Each participant received baseline measurements of blood HbA1c and inflammatory markers levels and repeated assessments of physical functioning over a mean follow-up period of 5.3 years. We used generalized linear mixed-effects regression to estimate the adjusted changes in the odds ratio for self-reported physical functioning impairment and Short Physical Performance Battery (SPPB) score according to baseline HbA1c levels (categorized into 0.5% increments from < .001). Compared with participants with an HbA1c of 5.5% to 48,124 pg/mL; p for interaction < .05). Conclusions: High and low HbA1c levels at baseline are associated with faster physical functioning decline, particularly among individuals with elevated circulating soluble interleukin-6 receptor, a sign of enhanced interleukin-6 trans-signaling.
    日期: 2019-06
    關聯: The Journals of Gerontology: Series A. 2019 Jun;74(6):949-956.
    Link to: http://dx.doi.org/10.1093/gerona/gly147
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1079-5006&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000475713200027
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85066847553
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