國家衛生研究院 NHRI:Item 3990099045/11264
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    題名: The role of sentrin-specific protease 2 substrate recognition in TGF-β-induced tumorigenesis
    其他題名: The role of sentrin-specific protease 2 substrate recognition in TGF-beta-induced tumorigenesis
    作者: Chang, CC;Huang, YS;Lin, YM;Lin, CJ;Jeng, JC;Liu, SM;Ho, TL;Chang, RT;Changou, CA;Ho, CC;Shih, HM
    貢獻者: Institute of Molecular and Genomic Medicine
    摘要: Smad4, a common-mediator of Smads, plays a central role in forming complexes with receptor-phosphorylated Smads, and then transduces transforming growth factor (TGF)-beta signals into the nuclei. Although many cellular factors are involved in TGF-beta induced epithelial-to-mesenchymal transition (EMT) and cell migration, very little is known with the mechanism of Smad4 regulation on pro-oncogenes response by TGF-beta. Herein, we demonstrate the interaction of Sentrin-specific protease 2 (SENP2) with Smad4 through SENP2 residue 363 similar to 400. The same segment is also important for desumoylation of Smad4, and able to relieve sumoylation-mediated TGF-beta repression. The SENP2363 similar to 400 segment is critical for TGF-beta-induced cell migration, which is correlated with SENP2363 similar to 400 deletion mutant failed to increase matrix metalloproteinase (MMP)-9 and EMT marker gene expression. Moreover, our results suggest that the interaction and desumoylation between SENP2 and Smad4 promote cell migration in triple-negative breast cancer cells. Altogether, our data show how SENP2 regulates its substrate for desumoylation, and also the role of SENP2 in TGF-beta induced cancer cell migration.
    日期: 2018-06
    關聯: Scientific Reports. 2018 Jun;8:Article number 9786.
    Link to: http://dx.doi.org/10.1038/s41598-018-28103-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000436546200007
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85049246824
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