國家衛生研究院 NHRI:Item 3990099045/1131

NHRI > Institute of Biotechnology and Pharmaceutical Research > Kak-Shan Shia > Periodical Articles > Item 3990099045/1131

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/1131

Title:	Synthesis and anticancer evaluation of vitamin K-3 analogues
Authors:	Chen, CP;Liu, YZ;Shia, KS;Tseng, HY
Contributors:	Division of Biotechnology and Pharmaceutical Research
Abstract:	Novel vitamin K-3 analogues were synthesized and evaluated for their anticancer activity. Compound 6, 9, 10, 11, 14, and (+/-)15 demonstrated a strong inhibitory activity against the tumor cells of A-549, Hep G2, MCF7, MES-SA, MES-SA/Dx5, MKN45, SW-480, and TW-039. Compound (+/-)15 displayed potent tumor cell cytotoxicity, and compound 14 selectively affected MCF7, even though it did not influence normal cells Detroit551 and WI-38. Compound (+/-)15 inhibited MES-SA and MES-SA/Dx5, and this specific result shows that compound (+/-)15 may become a good anticancer drug candidate. (C) 2002 Elsevier Science Ltd. All rights reserved.
Keywords:	Chemistry, Medicinal;Chemistry, Organic
Date:	2002-10-07
Relation:	Bioorganic and Medicinal Chemistry Letters. 2002 Oct;12(19):2729-2732.
Link to:	http://dx.doi.org/10.1016/S0960-894X(02)00532-2
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-894X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000178115700015
Cited Times(Scopus):	http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0037037395
Appears in Collections:	[Kak-Shan Shia] Periodical Articles

Files in This Item:

File	Description	Size	Format
000178115700015.pdf		102Kb	Adobe PDF	654	View/Open