國家衛生研究院 NHRI:Item 3990099045/11344
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11344


    Title: Independent association between subjective cognitive decline and frailty in the elderly
    Authors: Hsieh, TJ;Chang, HY;Wu, IC;Chen, CC;Tsai, HJ;Chiu, YF;Chuang, SC;Hsiung, CA;Hsu, CC
    Contributors: Institute of Population Health Sciences
    Abstract: BACKGROUND: The relationship between subjective cognitive decline and frailty, two components of the so-called reversible cognitive frailty, in the elderly remains unclear. This study aims to elucidate whether this association exists, independent of confounding factors such as nutritional status, kidney function, inflammation, and insulin resistance. METHODS: 2386 participants (>/= 65 years of age) selected from the Healthy Aging Longitudinal Study in Taiwan (HALST) study. Fried frailty phenotype was adopted to quantify frailty status. We classified cognitive status into two categories-subjective cognitive decline (SCD), and normal cognition-and used polytomous logistic regressions to investigate the associations between SCD and frailty. RESULTS: There were 188 (7.88%), 1228 (51.47%), and 970 (40.65%) participants with frailty, pre-frailty, and robustness, respectively. Compared to those with normal cognition, elders with SCD were more likely to have pre-frailty (odds ratio [OR]: 1.36, 95% confidence interval [CI]: 1.10-1.67, p = 0.004) or frailty (OR: 1.78, 95% CI: 1.23-2.58, p = 0.002) after adjusting for age, gender, education level, comorbidity, nutritional status, kidney function, and biochemical-related factors. CONCLUSIONS: A significant association between subjective cognitive decline and frailty was revealed in this study. Subjective cognitive decline was positively associated with pre-frailty or frailty even after adjusting for potential confounding factors. Our results can provide useful references in understanding mechanisms and developing suitable preventive strategies for the elderly with reversible cognitive frailty.
    Date: 2018-08-02
    Relation: PLoS ONE. 2018 Aug 2;13(8):Article number e0201351.
    Link to: http://dx.doi.org/10.1371/journal.pone.0201351
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000440778600035
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85051116841
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles
    [Chao A. Hsiung] Periodical Articles
    [Shu-Chun Chuang] Periodical Articles
    [Yen-Feng Chiu] Periodical Articles
    [Hui-Ju Tsai] Periodical Articles
    [Chu-Chih Chen] Periodical Articles
    [I-Chien Wu] Periodical Articles
    [Hsing-Yi Chang] Periodical Articles

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