國家衛生研究院 NHRI:Item 3990099045/11359
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    國家衛生研究院 NHRI > 癌症研究所 > 其他 > 期刊論文 >  Item 3990099045/11359


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    题名: Molecular targets in hepatocarcinogenesis and implications for therapy
    作者: Wu, MY;Yiang, GT;Cheng, PW;Chu, PY;Li, CJ
    贡献者: National Institute of Cancer Research
    摘要: Hepatocarcinogenesis comprises of multiple, complex steps that occur after liver injury and usually involve several pathways, including telomere dysfunction, cell cycle, WNT/beta-catenin signaling, oxidative stress and mitochondria dysfunction, autophagy, apoptosis, and AKT/mTOR signaling. Following liver injury, gene mutations, accumulation of oxidative stress, and local inflammation lead to cell proliferation, differentiation, apoptosis, and necrosis. The persistence of this vicious cycle in turn leads to further gene mutation and dysregulation of pro- and anti-inflammatory cytokines, such as interleukin (IL)-1beta, IL-6, IL-10, IL-12, IL-13, IL-18, and transforming growth factor (TGF)-beta, resulting in immune escape by means of the NF-kappaB and inflammasome signaling pathways. In this review, we summarize studies focusing on the roles of hepatocarcinogenesis and the immune system in liver cancer. In addition, we furnish an overview of recent basic and clinical studies to provide a strong foundation to develop novel anti-carcinogenesis targets for further treatment interventions.
    日期: 2018-08-13
    關聯: Journal of Clinical Medicine. 2018 Aug 13;7(8):Article number 213.
    Link to: http://dx.doi.org/10.3390/jcm7080213
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2077-0383&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000442602700033
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85067470086
    显示于类别:[其他] 期刊論文

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