國家衛生研究院 NHRI:Item 3990099045/11398
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    題名: The epidemiology of non-Candida yeasts isolated from blood: The Asia Surveillance Study
    作者: Lin, SY;Lu, PL;Tan, BH;Chakrabarti, A;Wu, UI;Yang, JH;Patel, AK;Li, RY;Watcharananan, SP;Liu, Z;Chindamporn, A;Tan, AL;Sun, PL;Hsu, LY;Chen, YC;Asia Fungal Working Group
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: BACKGROUND: Current guidelines recommend echinocandins as first-line therapy for candidemia. However, several non-Candida yeasts are non-susceptible to echinocandins (echinocandin non-susceptible yeast, ENSY), including Cryptococcus, Geotrichum, Malassezia, Pseudozyma, Rhodotorula, Saprochaete, Sporobolomyces, and Trichosporon. In laboratories that are not equipped with rapid diagnostic tools, it often takes several days to identify yeasts, and this may lead to inappropriate presumptive use of echinocandins in patients with ENSY fungemia. The aim of this study was to determine the distribution of ENSY species during a one-year, laboratory surveillance program in Asia. METHODS: Non-duplicate yeasts isolated from blood or bone marrow cultures at 25 hospitals in China, Hong Kong, India, Singapore, Taiwan and Thailand were analyzed. Isolates were considered to be duplicative if they were obtained within 7 days from the same patient. RESULTS: Of 2155 yeast isolates evaluated, 175 (8.1%) were non-Candida yeasts. The majority of non-Candida yeasts were ENSY (146/175, 83.4%). These included Cryptococcus (109 isolates), Trichosporon (23), Rhodotorula (10), and Malassezia (4). The proportion of ENSY isolates (146/2155, 6.7%) differed between tropical (India, Thailand and Singapore; 51/593, 8.6%) and non-tropical countries/regions (China, Hong Kong, and Taiwan; 95/1562, 6.1%, p=0.038). ENSY was common in outpatient clinics (25.0%) and emergency departments (17.8%), but rare in intensive care units (4.7%) and in hematology-oncology units (2.9%). Cryptococcus accounted for the majority of the non-Candida species in emergency departments (21/24, 87.5%) and outpatient clinics (4/5, 80.0%). CONCLUSIONS: Isolation of non-Candida yeasts from blood cultures was not rare, and the frequency varied among medical units and countries.
    日期: 2019-02
    關聯: Mycoses. 2019 Feb;62(2):112-120.
    Link to: http://dx.doi.org/10.1111/myc.12852
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0933-7407&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000457396900004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85055054199
    顯示於類別:[陳宜君] 期刊論文

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