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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/11413
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| Title: | Effects of statin use in advanced chronic kidney disease patients |
| Authors: | Huang, TM;Wu, VC;Lin, YF;Wang, JJ;Shiao, CC;Chen, L;Chueh, SJ;Chueh, E;Yang, SY;Lai, TS;Lin, SL;Chu, TS;Wu, KD;National Taiwan University Hospital Study Group on Acute Renal Failure |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Although statin treatment is recommended for patients with chronic kidney disease (CKD) stages I(-)IV, its potential benefits have not been reported in advanced CKD patients. Non-diabetic patients with advanced CKD (pre-dialysis patients, estimated glomerular filtration rate <15 mL/min/1.73 m(2)) were enrolled from a National Health Insurance Research Database with a population of 23 million. Statin users and non-users were matched using propensity scoring and analyzed using Cox proportional hazards models, taking mortality as a competing risk with subsequent end-stage renal disease (ESRD) and statin doses as time-dependent variables. A total of 2551 statin users and 7653 matched statin non-users were identified from a total 14,452 patients with advanced CKD. Taking mortality as a competing risk, statin use did not increase the risk of new-onset diabetes mellitus (NODM) or decrease the risk of de novo major adverse cardiovascular events (MACE), but reduced all-cause mortality (hazard ratio (HR) = 0.59 [95% CI 0.42(-)0.84], p = 0.004) and sepsis-related mortality (HR = 0.53 [95% CI 0.32(-)0.87], p = 0.012). For advanced CKD patients, statin was neither associated with increased risks of developing NODM, nor with decreased risk of de novo MACE occurrence, but with a reduced risk of all-cause mortality, mainly septic deaths. |
| Date: | 2018-09-17 |
| Relation: | Journal of Clinical Medicine. 2018 Sep 17;7(9):Article number 285. |
| Link to: | http://dx.doi.org/10.3390/jcm7090285 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2077-0383&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000445635800059 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85114272652 |
| Appears in Collections: | [陳麗光] 期刊論文
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