國家衛生研究院 NHRI:Item 3990099045/11418
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    题名: Maternal folic acid supplementation during pregnancy in relation to childhood rhinitis: A cohort study in Taiwan
    作者: Tsai, Z;Huang, Y;Huang, Y;Lin, C;Fang, H;Chiu, C;Kao, P;Weng, T;Lu, K;Lee, W;Gau, C;Tsai, H;Yao, T
    贡献者: Institute of Population Health Sciences
    摘要: Background: Folic acid supplementation (FAS) during pregnancy has been suggested due to its protective effect against neural tube defects. At present the effect of FAS during pregnancy on childhood rhinitis has remained unclear. We aimed to investigate the relationship between FAS during pregnancy and childhood rhinitis. Method: A total of 613 children (age 6.3 ± 0.3 years; 345 boys, 56.3%) participated in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort were included in this study. All study subjects were interviewed by board‐certified pediatricians; and demographic, epidemiologic and clinical data were collected based on a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Maternal FAS during pregnancy was categorized into three groups (never; <3 months; and >=3 months). Atopy status was determined by Phadiatop Infant. Logistic regression analysis with covariate adjustment was performed. Adjusted covariates included sex, age, number of older siblings, breast feeding duration, maternal smoking during pregnancy, maternal allergy, maternal education level, maternal age and socioeconomic status Results: The prevalence of physician‐diagnosed rhinitis was 55.3%. There is a significant association between FAS and physician‐diagnosed rhinitis (adjusted odds ratio [AOR] = 2.07; 95% confidence interval [CI] = 1.25‐3.43 for FAS ≥3 months) compared to the group of never use. In the stratified analysis by atopy status, maternal FAS during pregnancy was significantly associated with physician‐diagnosed rhinitis in the atopic group (AOR = 1.91, 95% CI = 1.07‐3.40 for FAS <3 months; and AOR = 2.34, 95% CI = 1.19‐4.58 for FAS ≥3 months), but not in the non‐atopic group. When further stratified by gender, significant association between maternal FAS during pregnancy and physician‐diagnosed rhinitis was only found in boys with atopy (AOR = 3.23, 95% CI = 1.39‐7.50 for FAS <3 months; and AOR = 4.02, 95% CI = 1.51‐10.72 for FAS ≥3 months). Conclusion: The results demonstrate that maternal folic acid supplementation during pregnancy might increase the risk of childhood rhinitis, especially among boys with atopy. Further investigation will be needed to validate our findings and to understand potential underlying mechanisms.
    日期: 2018-08
    關聯: Allergy. 2018 Aug;73(Suppl. 105):679.
    Link to: http://dx.doi.org/10.1111/all.13539
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000441690405011
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