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http://ir.nhri.org.tw/handle/3990099045/11421
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| Title: | Maternal pre-pregnancy overweight/obesity and development of allergic rhinitis and asthma in their offspring at age of 6 years |
| Authors: | Fang, H;Lin, C;Huang, Y;Huang, Y;Tsai, Z;Chiu, C;Kao, P;Lu, K;Lee, W;Chun-Chun, G;Tsai, H;Yao, T |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Background: Previous studies have reported the positive association between maternal pre ‐ pregnancy overweight / obesity and asthma in early childhood of their offspring, although the evidence supporting the association is inconclusive. The objective of this study was to determine the effects of maternal pre ‐ pregnancy overweight / obesity on asthma and allergic rhinitis among their children at 6 years of age. Method: his study included 613 children enrolled in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort (age 6.3 ± 0.3 years; 345 boys, 56.3%). Information about maternal pre ‐ pregnancy BMI was ascertained by a questionnaire. Asthma and allergic rhinitis were diagnosed based on a physician interview. Adjusted odds ratios (AORs) and 95% confidence interval (CI) were calculated by logistic regression with adjustment for relevant confounding factors, such as age, gender, birth weight, child ' s body mass index, maternal age, number of older siblings and maternal history of allergic diseases. Results: In this study, 14.2% (n = 79) of children born to mothers with pre ‐ pregnancy overweight / obesity, defined as body mass index (BMI) equal to 25.0 or more before pregnancy; 15.1% (n = 84) and 50.8% (n = 283) of children developed physician ‐ diagnosed asthma and allergic rhinitis, respectively. Compared to mothers with pre ‐pregnancy normal weight, we found no significant association of maternal pre ‐ pregnancy overweight / obesity with asthma (AOR = 1.53; 95% CI = 0.77 ‐ 3.06) or allergic rhinitis (AOR = 1.71; 95% CI = 0.99 ‐ 2.95) among their offspring. Conclusion: Our results suggest that maternal pre ‐ pregnancy overweight / obesity may not be a significant risk factor on development of asthma or allergic rhinitis in offspring at early school age. Further research with a larger sample size is needed to confirm the findings in this study. |
| Date: | 2018-08 |
| Relation: | Allergy. 2018 Aug;73(Suppl. 105):333. |
| Link to: | http://dx.doi.org/10.1111/all.13537 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000441690401393 |
| Appears in Collections: | [蔡慧如] 會議論文/會議摘要
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| ISI000441690401393.pdf | 44Kb | Adobe PDF | 268 | View/Open |
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