國家衛生研究院 NHRI:Item 3990099045/11423

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Title:	Examine the relationship between maternal vitamin D supplementation during pregnancy and eczema in their offspring in a cohort study of children aged 6 years
Authors:	Lu, K;Huang, Y;Huang, Y;Tsai, Z;Chiu, C;Lin, C;Fang, H;Kao, P;Lee, W;Gau, C;Tsai, H;Yao, T
Contributors:	Institute of Population Health Sciences
Abstract:	Background: Vitamin D has been known for its complex roles in the immune system. Limited studies have reported the effect of maternal vitamin D supplementation during pregnancy on the development of eczema in their offspring. The objective of this study was to investigate the relationship between maternal intake of vitamin D supplements during pregnancy and eczema in their offspring at age of 6 years. Method: We included 613 children born in Chang Gung Memorial Hospital in 2010‐2011, participating in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) Cohort. Clinical data evaluated by pediatricians, epidemiologic questionnaires, and serum for measurement of allergen‐specific immunoglobulin E were collected for children aged 6 years. Atopy was defined by Phadiatop Infant. Logistic regression models with covariates adjustment were carried out to examine the association between maternal intake of vitamin D supplements during pregnancy and offspring developing physician‐diagnosed eczema later on. Results: Maternal intake of vitamin D supplements during pregnancy was associated with a higher risk of physician‐diagnosed eczema in children at 6 years of age (adjusted odds ratio [AOR]: 1.97, 95% CI: 1.24‐3.12; P = 0.004). There was also a significant relationship between current eczema and maternal intake of vitamin D supplements for more than or equal to three months during pregnancy (AOR: 2.12, 95%CI: 1.20‐3.72; P = 0.009). Physician‐diagnosed eczema was also significantly related to family history of atopic eczema, birth weight, cat exposure during pregnancy and socioeconomic status. Subgroup analyses based on atopy revealed significant association of maternal vitamin D supplementation during pregnancy with physician‐diagnosed eczema among non‐atopic children (AOR: 3.47, 95% CI: 1.42‐8.46; P = 0.006), while the association is of borderline significance among atopic children (AOR: 1.77, 95% CI: 0.98‐3.21; P = 0.059), after adjustment for relevant confounders. Conclusion: Our results suggest that maternal vitamin D supplementation during pregnancy may increase the risk of eczema in children at 6 years of age. Further studies with larger sample size is necessary to confirm this association.
Date:	2018-08
Relation:	Allergy. 2018 Aug;73(Suppl. 105):296.
Link to:	http://dx.doi.org/10.1111/all.13537
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000441690401318
Appears in Collections:	[Hui-Ju Tsai] Conference Papers/Meeting Abstract

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