國家衛生研究院 NHRI:Item 3990099045/11425
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    題名: Influence of frequency and timing of cockroach exposure on atopic dermatitis in a cohort study in Taiwan
    作者: Kao, P;Huang, Y;Huang, Y;Tsai, Z;Chiu, C;Lu, K;Fang, H;Lin, C;Gau, C;Lee, W;Tsai, H;Yao, T
    貢獻者: Institute of Population Health Sciences
    摘要: Background: At present, previous studies have reported inconsistent association between frequency and timing of cockroach exposure and atopic dermatitis (AD). This study aimed to investigate the association between frequency and timing of cockroach exposure and AD in a cohort study of children aged 6‐7 years. Method: A total of 613 children (345 boys, 56.3%; mean age, 6.3 years) participated in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort were included in this study. The frequency of cockroach exposure (never; less than or equal to three times per month; and more than three times per month) was collected at three time points, including during maternal pregnancy, 12 months after birth, and recent 1 year. AD disease status were acquired by a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Atopy status was determined by Phadiatop Infant. Multivariable regression models controlling for sex, maternal AD and paternal AD were applied to determine the associations of frequency of cockroach exposure at three time points with AD among children. Results: In this study, we found that cockroach exposure more than three times per month during the 12 months after birth reduced the risk of AD (comparing to never exposed group) (adjusted odds ratio [AOR] = 0.26; 95% confidence interval [CI] = 0.12‐ 0.58), but no significant result was found for children exposed to cockroach less than or equal to three times per month during the 12 months after birth. When examining gender effect, the protective effect was only found in boys (AOR = 0.19; 95% CI = 0.07‐0.57), but not in girls. We also grouped study children by atopy status, significant association was found in children with atopy (AOR = 0.20; 95% CI = 0.07‐0.55), but not those without atopy. No significant association was found for the frequency of cockroach exposure during maternal pregnancy or recent 1 year. Conclusion: Our results indicate significant association between cockroach exposure more than three times per month during 12 months after birth and atopic dermatitis in children. The clinical benefit may be greater in boys or those with atopy. Further studies with a larger sample size are warranted to confirm the protective effect observed in this study.
    日期: 2018-08
    關聯: Allergy. 2018 Aug;73(Suppl. 105):167.
    Link to: http://dx.doi.org/10.1111/all.13537
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000441690401070
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