國家衛生研究院 NHRI:Item 3990099045/11489
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 12145/12927 (94%)
Visitors : 853981      Online Users : 1374
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
    •  Adv. Search
    Home ‧ Login ‧ Upload ‧ Help ‧ About ‧ Administer Goto mobile version


    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11489


    Title: The influence of prediagnosis alcohol consumption and the polymorphisms of ethanol metabolizing genes on the survival of head and neck cancer patients
    Authors: Lee, WT;Hsiao, JR;Ou, CY;Huang, CC;Chang, CC;Tsai, ST;Chen, KC;Huang, JS;Wong, TY;Lai, YH;Wu, YH;Hsueh, WT;Wu, SY;Yen, CJ;Chang, JY;Lin, CL;Weng, YL;Yang, HC;Chen, YS;Chang, JS
    Contributors: National Institute of Cancer Research
    Abstract: BACKGROUND: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pre-treatment alcohol consumption and the overall survival (OS) of HNC patients. METHODS: Cox proportional hazards models were performed to evaluate the association between pre-diagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two ethanol metabolizing genes, ADH1B and ALDH2, on this relationship was also evaluated. RESULTS: The results showed a significant positive dose-response relationship between pre-diagnosis alcohol use and worse OS of HNC patients. This association was more significant for oropharyngeal cancer, hypopharyngeal cancer, and laryngeal cancer than for oral cancer. The association between alcohol use and the poorer OS of HNC patients was mainly through its association with a higher stage of HNC at diagnosis. The worst OS associated with alcohol use was observed among HNC patients with the fast ADH1B and the slow/non-functional ALDH2 genotype combination. CONCLUSIONS: Our analysis showed a significant positive dose-response relationship between pre-diagnosis alcohol use and a worse OS of HNC. This association was mainly due to the higher stage of HNC among alcohol drinkers. In addition, the polymorphisms of the ethanol metabolizing gene, ADH1B and ALDH2, modified the relationship between pre-diagnosis alcohol use and the OS of HNC patients. IMPACT: Pre-diagnosis alcohol use may be a prognostic indicator of HNC.
    Date: 2019-02
    Relation: Cancer Epidemiology, Biomarkers and Prevention. 2019 Feb;28(2):248-257.
    Link to: http://dx.doi.org/10.1158/1055-9965.Epi-18-0425
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1055-9965&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000465321600002
    Appears in Collections:[Jeffrey Shu-Ming] Periodical Articles
    [Jang-Yang Chang] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    PUB30275114.pdf887KbAdobe PDF360View/Open


    All items in NHRI are protected by copyright, with all rights reserved.

    Related Items in TAIR

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback