國家衛生研究院 NHRI:Item 3990099045/1148
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    題名: Inhibition of authentic hepatitis C virus replication by sodium stibogluconate
    作者: Yeh, CT;Hwang, DR;Lai, HY;Hsu, JTA
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: Using a hepatitis C virus (HCV) subgenomic RNA replicon system, drugs currently being used to treat other human diseases were examined for their antiviral activities against HCV. Several drugs including sodium stibogluconate, a compound used to treat leishmaniasis, were capable of suppressing replication of HCV replicon. The antiviral effect of sodium stibogluconate was subsequently verified using a cell line (293EBNA-Sip-L) previously proved to be permissive for HCV infection/replication. An ex vivo assay using fresh human liver slices established and a panel of human liver slices was obtained from biopsy samples of patients infected with HCV was used to examine the antiviral activity of this drug. A nearly complete suppression effect was achieved in four of six human liver slices at the drug concentration of 100 mug/ml, lower than what was required to treat leishmaniasis. A human trial is mandatory to understand its clinical value in treating chronic hepatitis C. (C) 2003 Elsevier Inc. All rights reserved.
    關鍵詞: Biochemistry & Molecular Biology;Biophysics
    日期: 2003-10-17
    關聯: Biochemical and Biophysical Research Communications. 2003 Oct;310(2):537-541.
    Link to: http://dx.doi.org/10.1016/j.bbrc.2003.09.055
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0006-291X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000185904300042
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0141682001
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