國家衛生研究院 NHRI:Item 3990099045/11539
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    题名: Wharton' jelly mesenchymal stromal cell therapy for ischemic brain injury
    作者: Wu, KJ;Yu, SJ;Chiang, CW;Lee, YW;Yen, BL;Hsu, CS;Kuo, LW;Wang, Y
    贡献者: Center for Neuropsychiatric Research;Institute of Biomedical Engineering and Nanomedicine;Institute of Cellular and Systems Medicine
    摘要: Increasing evidence have supported that Wharton's jelly mesenchymal stem cell (WJ-MSCs) have immunomodulatory and protective effects against several diseases including kidney, liver pathologies, and heart injury. Few in vitro studies have reported that WJ-MSCs reduced inflammation in hippocampal slices after oxygen-glucose deprivation. We recently reported the neuroprotective effects of human WJ-MSCs (hWJ-MSCs) in rats exposed to a transient right middle cerebral artery occlusion. hWJ-MSCs transplantation significantly reduced brain infarction and microglia activation in the penumbra leading with a significant reduction of neurological deficits. Interestingly, the grafted hWJ-MSCs in the ischemic core were mostly incorporated into IBA1 (+) cells, suggesting that hWJ-MSCs were immunorejected by the host. The immune rejection of hWJ-MSCs was reduced in after cyclosporine A treatment. Moreover, the glia cell line-derived neurotrophic factor expression was significantly increased in the host brain after hWJ-MSCs transplantation. In conclusion, these results suggest that the protective effect of hWJ-MSCs may be due to the secretion of trophic factors rather than to the survival of grafted cells. This paper is a review article. Referred literature in this paper has been listed in the references section. The data sets supporting the conclusions of this article are available online by searching various databases, including PubMed. Some original points in this article come from the laboratory practice in our research center and the authors' experiences.
    日期: 2018-07
    關聯: Brain Circulation. 2018 Jul-Sep;4(3):124-127.
    Link to: http://dx.doi.org/10.4103/bc.bc_16_18
    显示于类别:[王昀] 期刊論文
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