國家衛生研究院 NHRI:Item 3990099045/1154
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    題名: Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide
    作者: Wu, CJ;Jan, JT;Chen, CM;Hsieh, HP;Hwang, DR;Liu, HW;Liu, CY;Huang, HW;Chen, SC;Hong, CF;Lin, RK;Chao, YS;Hsu, JTA
    貢獻者: Division of Biotechnology and Pharmaceutical Research
    摘要: Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 muM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.
    關鍵詞: Microbiology;Pharmacology & Pharmacy
    日期: 2004-07
    關聯: Antimicrobial Agents and Chemotherapy. 2004 Jul;48(7):2693-2696.
    Link to: http://dx.doi.org/10.1128/AAC.48.7.2693-2696.2004
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0066-4804&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000222427200049
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=3042675488
    顯示於類別:[徐祖安] 期刊論文
    [謝興邦] 期刊論文
    [趙宇生(2002-2013)] 期刊論文

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