國家衛生研究院 NHRI:Item 3990099045/11560

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Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11560

Title:	A handheld real-time photoacoustic imaging system for animal neurological disease models: From simulation to realization
Authors:	Liu, YH;Xu, Y;Liao, LD;Chan, KC;Thakor, NV
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	This article provides a guide to design and build a handheld, real-time photoacoustic (PA) imaging system from simulation to realization for animal neurological disease models. A pulsed laser and array-based ultrasound (US) platform were utilized to develop the system for evaluating vascular functions in rats with focal ischemia or subcutaneous tumors. To optimize the laser light delivery, finite element (FE)-based simulation models were developed to provide information regarding light propagation and PA wave generation in soft tissues. Besides, simulations were also conducted to evaluate the ideal imaging resolution of the US system. As a result, a PA C-scan image of a designed phantom in 1% Lipofundin was reconstructed with depth information. Performance of the handheld PA system was tested in an animal ischemia model, which revealed that cerebral blood volume (CBV) changes at the cortical surface could be monitored immediately after ischemia induction. Another experiment on subcutaneous tumors showed the anomalous distribution of the total hemoglobin concentration (HbT) and oxygen saturation (SO(2)), while 3D and maximum intensity projection (MIP) PA images of the subcutaneous tumors are also presented in this article. Overall, this system shows promise for monitoring disease progression in vascular functional impairments.
Date:	2018-11-21
Relation:	Sensors. 2018 Nov 21;18(11):Article number 4081.
Link to:	http://dx.doi.org/10.3390/s18114081
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1424-8220&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000451598900491
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85057114468
Appears in Collections:	[Lun-De Liao] Periodical Articles

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