國家衛生研究院 NHRI:Item 3990099045/11580
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    題名: Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist
    作者: Chang, CP;Huang, HL;Huang, JK;Hung, MS;Wu, CH;Song, JS;Lee, CJ;Yu, CS;Shia, KS
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: The [18F] isotope-labelled CB1 inverse agonist 3 was elaborated and synthesized for positron emission tomography scanning studies. After immediate purification and calibration with its unlabeled counterpart, compound 3 was intravenously injected in mice and revealed that its distribution percentage in brain over 90-min scans among five region of interests, including brain, liver, heart, thigh muscle and kidney was lower than 1%, thus providing direct evidence to justify itself as a peripherally restricted CB1 antagonist.
    日期: 2019-01-01
    關聯: Bioorganic and Medicinal Chemistry. 2019 Jan 1;27(1):216-223.
    Link to: http://dx.doi.org/10.1016/j.bmc.2018.11.043
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0968-0896&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000453233300022
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85057791630
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