國家衛生研究院 NHRI:Item 3990099045/11584
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    题名: Prognostic significance of 14-3-3epsilon, aldo-keto reductase family 1 B10 and metallothionein-1 in hepatocellular carcinoma
    其它题名: Prognostic significance of 14-3-3ε, aldo-keto reductase family 1 B10 and metallothionein-1 in hepatocellular carcinoma
    作者: Wu, CY;Jan, YJ;Ko, BS;Wu, YJ;Wu, YJ;Liou, JY
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Background/Aim: Expression of 14-3-3ε is associated with prognostic outcomes of hepatocellular carcinoma (HCC) patients. Metallothionein-1 (MT-1) proteins and aldo-keto-reductase family 1 B10 (AKR1B10) are considered potential tumor regulators of HCC. The aim of this study, was to examine the prognostic value of 14-3-3ε, MT-1 and AKR1B10 expression in HCC. Materials and Methods: The expression levels of 14-3-3ε, MT-1 and AKR1B10 in HCC cell lines and paraffin-embedded tissues were examined by western blotting and immunohistochemical analysis. Results: 14-3-3ε positivity was significantly associated with decreased MT-1 expression in HCC. Patients with decreased MT-1 expression had worse survival rates and a higher risk of metastasis than 14-3-3ε-positive HCC patients with unchanged MT-1 expression. Distinct expression patterns of 14-3-3ε/MT-1/AKR1B10 were significantly associated with the metastatic incidence and survival rates of HCC patients. Patients with negative 14-3-3ε staining in primary tumors had better prognostic outcomes. In contrast, patients with positive 14-3-3ε staining, decreased MT-1 expression and no increase in AKR1B10 expression in primary tumors had the worst overall and disease-free survival rates and the highest metastatic risk. Conclusion: 14-3-3ε, AKR1B10, and MT-1 act as potential prognostic biomarkers of HCC.
    日期: 2018-12
    關聯: Anticancer Research. 2018 Dec;38(12):6855-6863.
    Link to: http://dx.doi.org/10.21873/anticanres.13060
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-7005&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000451742800035
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85057567316
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