國家衛生研究院 NHRI:Item 3990099045/11590
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11590


    Title: Intense pulsed light combined with alpha-hydroxy acid peels in treatment of chloasma
    Authors: Liao, CF;Liao, HC;Lee, MC;Meng, SH;Li, JM;Yang, M;Yang, S
    Contributors: Institute of Population Health Sciences
    Abstract: Objective: To investigate the effect of intense pulsed light (IPL) plus alpha-hydroxy acid peels in patients with chloasma. Methods: Sixty chloasma patients were enrolled from Department of Dermatology in No. 1 Hospital, Anhui Medical University between January 2015 and December 2017. The included patients were randomly divided into two groups, namely the test group and the control group. Patients in the test group underwent alpha-hydroxy acid peels and IPL, while those in the control group were given alpha-hydroxy acid peels alone. The treatment period was 8 weeks in both groups, with 30 patients in each group. The curative effect, overall skin lesion scores, patient satisfaction, adverse reactions, and serum superoxide dismutase (SOD) and malondialdehyde (MDA) expression were compared between the two groups. Results: The test group had an overall response rate of 86.7%, which was significantly higher than that (60%) in the control group, and the difference was statistically significant (P=0.017). The scores of patient satisfaction in the test group was significantly higher than that in the control group (3.2 +/- 0.7 vs. 2.4 +/- 0.5, P<0.001). The two groups had significantly lower overall skin lesion scores, higher SOD levels, but lower MDA levels after treatment than before treatment (all P<0.05). After treatment, patients in the test group showed significantly lower overall skin lesion scores (P<0.001), higher SOD levels (P<0.001), and lower MDA levels (P=0.001) than those in the control group. Differences in the incidence of adverse reactions were not significant different between the two groups (P=0.639). Conclusion: IPL combined with alpha-hydroxy acid peels exhibits obvious anti-oxidation effect. It can effectively cure chloasma and induce few adverse reactions, thereby leading to wide clinical application.
    Date: 2018-12
    Relation: International Journal of Clinical and Experimental Medicine. 2018 Dec;11(11):12474-12480.
    Link to: http://www.ijcem.com/files/ijcem0081453.pdf
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000451862900125
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85103099396
    Appears in Collections:[Meng-Chih Lee] Periodical Articles

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