國家衛生研究院 NHRI:Item 3990099045/11608
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    题名: Targeting PTX3 can prevent drug-resistant cancer progression
    作者: Wang, JM;Chi, JY;Hsiao, YW;Li, CF;Lo, YC;Lin, ZY;Hong, JY;Liu, YM;Han, X;Wang, SM;Chen, BK;Tsai, KK
    贡献者: National Institute of Cancer Research
    摘要: The tumor microenvironment has been suggested to participate in tumorigenesis, but the nature of the communication between cancer cells and the icroenvironment, especially in response to anticancer drugs, remains obscure. We determined that activation of the CCAAT/enhancer binding protein delta (CEBPD) response to Cisplatin and 5-Fluorouracil in cancer-associated macrophages and fibroblasts contributed to the metastasis, invasion, acquired chemoresistance and stemness of cancer cells. Specifically, CEBPD induction in macrophages and fibroblasts activates Pentraxin 3 (PTX3) expression. PTX3 promotes the expansion of breast cancer and that CEBPD and PTX3 expression in the stroma was associated with inferior disease-specific and metastasis-free survival in primary localized breast cancer. These finding sug­gest that PTX3 has a protumor activity and attributed to its protein inhibitors could function as promising drug for preventing cancer progression and the metastasis, invasion and progression of drug-resistant cancers.
    日期: 2018-11
    關聯: Protein Science. 2018 Nov;27(Suppl. 1):24.
    Link to: https://doi.org/10.1002/pro.3513
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0961-8368&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000450682700022
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